Human Molecular Genetics

Tom Strachan, Andrew Read

674 pages, parution le 15/10/2003 (3^eme édition)

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Résumé

With this fully updated third edition, Human Molecular Genetics enters the post-genome era. The content and organization have been thoroughly revised to take account of the new knowledge and new emphases in human molecular genetics now that we have the human genome sequence.

Introductory chapters cover DNA structure and function, chromosomes, pedigrees and the basic techniques of PCR, cloning and hybridization, and now include a new chapter on cells and development. Later chapters detail our new understanding of the structure, organization, expression and evolution of the human genome, and the progress of the many parallel genome projects.

Sections on variation, mutation and disease relate this knowledge to Mendelian diseases, complex multifactorial diseases and cancer. Mapping and identification of disease genes, molecular pathology and molecular diagnosis are treated in depth. The final sections cover functional genomics, the role of animal models and new approaches to genetic treatment of disease.

Overall, Human Molecular Genetics provides a complete, up-to-the-minute account of human molecular genetics in the post-genome era, from basic principles to current practice. Human Molecular Genetics is carefully designed to engage and motivate students with clear yet detailed full-color illustrations, special topic boxes (including coverage of ethical, legal and social issues such as eugenics, genetic testing and human cloning) and a constant emphasis on understanding principles rather than memorizing detail.

L'auteur - Tom Strachan

Scientific director of the Institute of Human Genetics and professor of Human Molecular Genetics at the University of Newcastle.

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L'auteur - Andrew Read

Andrew Read - Professeur de génétique humaine.

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Sommaire

The basics
- DNA structure and gene expression
- Chromosome structure and function
- Cells and development
- Genes in pedigrees and populations
- Amplifying DNA : PCR and cell-based DNA cloning
- Nucleic acid hybridization : principles and applications
- Analyzing DNA and gene structure, variation and expression
The human genome and its relationship to other genomes
- Genome projects ans model organisms
- Organization of the human genome
- Human gene expression
- Instability of the human genome : mutation and DNA repair
- Our place in the tree of life
Mapping and identifying disease genes and mutations
- Genetic mapping of mendelian characters
- Identifying human disease genes
- Mapping and identifying genes conferring susceptibility to complex diseases
- Molecular pathology
- Cancer genetics
- Genetic testing in individuals and populations
New horizons : into the 21st century
- Beyond the genome project : functional genomics, proteomics and bioinformatics
- Genetic manipulation of cells and animals
- New approaches to treating disease

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Caractéristiques techniques

	PAPIER
Éditeur(s)	Taylor and Francis Books
Auteur(s)	Tom Strachan, Andrew Read
Parution	15/10/2003
Édition	3^eme édition
Nb. de pages	674
Format	21,5 x 28,5
Couverture	Relié
Poids	2085g
Intérieur	Quadri
EAN13	9780815341826
ISBN13	978-0-8153-4182-6