Consanguinity, imbreeding, and genetic drift in italy

Luigi Luca Cavalli-Sforza, Antonio Moroni, Gianna Zei - Collection Monographs in population biology

316 pages, parution le 01/06/2004

Ajouter à une liste

Indisponible

Résumé

In 1951, the geneticist Luigi Luca Cavalli-Sforza was teaching in Parma when a student-a priest named Antonio Moroni- told him about rich church records of demography and marriages between relatives. After convincing the Church to open its records, Cavalli-Sforza, Moroni, and Gianna Zei embarked on a landmark study that would last fifty years and cover all of Italy. This book assembles and analyzes die team's research for the first time.

Using blood testing as well as church records, the team investigated the frequency of consanguineous marriages and its use for estimating inbreeding and studying the relations between inbreeding and drift. They tested the importance of random genetic drift by studying population structure through demography of the last three centuries, using it to predict the spatial variation of frequencies of genetic markers. The authors find that drift-related genetic variation, including its stabilization by migration, is best predicted by computer simulation. They also analyze the usefulness and limits of the concept of deme for defining Mendelian populations. The genetic effect of consanguineous marriage on recessive genetic diseases and for the detection of dominance in metric characters is also studied.

Ultimately bringing together the many strands of their massive project, Cavalli-Sforza, Moroni, and Zei are able to map genetic drift in all of Italy's approximately 8,000 communes and to demonstrate the relationship between each locality's drift and various ecological and demographic factors. In terms of both methods and findings, their accomplishment is tremendously important for understanding human social structure and the genetic effects of drift and inbreeding.

L'auteur - Luigi Luca Cavalli-Sforza

Mondialement connu pour ses recherches en génétique des populations, Luca Cavalli-Sforza est professeur émérite à l'Université Stanford, aux États-Unis. Il est l'auteur, notamment, de Gènes, Peuples et Langues, d'Évolution biologique, évolution culturelle, de La Science du bonheur et de Génétique des populations.

Autres livres de Luigi Luca Cavalli-Sforza

L'aventure de l'espèce humaine

Qui sommes-nous ?

La science du bonheur

La génétique des populations

Découvrir tous les livres de Luigi Luca Cavalli-Sforza

Sommaire

History of this investigation and structure of this book
Customs and legislation affecting consanguineous marriages, with special attention to the catholic church
Demographic factors affecting the frequencies of consanguineous marriage - A study in Northem Emilia
Probability of consanguineous marriages
Consanguinity, inbreeding, and observed genetic drift in the parma valley
A computer simulation of the upper parma valley population
Islands
Effects of inbreeding on normal and pathological phenotypes
Consanguineous marriages in Italy: data from the Vatican archives
Geography of demes in Italy

Voir tout

Replier

Caractéristiques techniques

	PAPIER
Éditeur(s)	Princeton University Press
Auteur(s)	Luigi Luca Cavalli-Sforza, Antonio Moroni, Gianna Zei
Collection	Monographs in population biology
Parution	01/06/2004
Nb. de pages	316
Format	14 x 21,5
Couverture	Broché
Poids	375g
Intérieur	Noir et Blanc
EAN13	9780691089928
ISBN13	978-0-691-08992-8