Forensic DNA Typing

Biology, Technology, and Genetics behind STR Markers

John Butler - Collection DNA Technology / Forensic Science

675 pages, parution le 29/04/2005

Ajouter à une liste

Indisponible

Résumé

Since the enormously successful first edition of Forensic DNA Typing was published, the Human Genome Project has published a draft sequence of the human genome and completed the "finished" reference sequence. The advent of modern DNA technology has resulted in the increased ability to perform human identity testing-desirable in a number of situations including the determination of perpetrators of violent crime such as murder and rape, resolving unestablished paternity, and identifying remains of missing persons or victims of mass disasters. The technology has been utilized in identifying remains from victims of the World Trade Center twin towers collapse following the terrorist attacks of September 11, 2001, the President Clinton-Monica Lewinsky scandal, and the identification of the remains in the Tomb of the Unknown Soldier. Indeed, our perceptions of history have been changed with DNA evidence that revealed Thomas Jefferson fathered a child by one of his slaves. This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century.

L'auteur - John Butler

John Butler : National Institute of Standards and Technology, Gaithersburg, Maryland, USA

John Butler earned his Ph.D. from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He designed and built STRBase--an Internet-accessible database on short tandem repeat DNA markers that is widely used by forensic scientists today. He is a frequent author and presenter on the topic of DNA typing.

Author of:
Forensic DNA TypingBiology, Technology, and Genetics behind STR Markers

Sommaire

Ch. 1: Overview & History of DNA Typing
BIOLOGY:
- Ch. 2: DNA Biology Review
- Ch. 3: Sample Collection, DNA Extraction, & DNA Quantitation
- Ch. 4: The Polymerase Chain Reaction (DNA Amplification)
- Ch. 5: Commonly Used Short Tandem Repeat Markers and Commercial Kits
- Ch. 6: Biology of STRs
- Ch. 7: Forensic Issues
- Ch. 8: Single Nucleotide Polymorphisms & Other Bi-allelic Markers
- Ch. 9: Y-Chromosome DNA Testing
- Ch. 10: Mitochondrial DNA Analysis
- Ch. 11: Non-Human DNA and Microbial Forensics
TECHNOLOGY:
- Ch. 12: DNA Separation Methods
- Ch. 13: DNA Detection Methods
- Ch. 14: Instrumentation for STR Typing
- Ch. 15: STR Genotyping Issues
- Ch. 16: Laboratory Validation
- Ch. 17: New Technologies, Automation, and Expert Systems
- Ch. 18: CODIS and DNA Databases
GENETICS:
- Ch. 19: Basic Genetic Principles, Statistics, & Probability
- Ch. 20: STR Population Database Analyses
- Ch. 21: Profile Frequency Estimates, Likelihood Ratios & Source Attribution
- Ch. 22: Approaches to Statistical Analysis of Mixtures & Degraded DNA
- Ch. 23: Kinship and Parentage Testing
BIOLOGY, TECHNOLOGY & GENETICS:
- Ch. 24: Mass Disaster DNA Victim Identification
- App I: Reported STR Alleles
- App II: Population Data-STR Allele Frequencies
- App. III: Suppliers of DNA Analysis Supplies
- App. IV: DAB QA Standards
- App. V: DAB Recommendations on Statistics
- App. VI: NRC II Recommendations
- App. VII: Example DNA Cases

Voir tout

Replier

Caractéristiques techniques

	PAPIER
Éditeur(s)	Elsevier, Academic Press
Auteur(s)	John Butler
Collection	DNA Technology / Forensic Science
Parution	29/04/2005
Nb. de pages	675
Format	19,5 x 25,5
Couverture	Relié
Poids	2000g
Intérieur	Noir et Blanc
EAN13	9780121479527
ISBN13	978-0-12-147952-7