Résumé
cost-effective processes for preparing large amounts of the target compound and
intermediates. The key to rapid and successful process development is avoiding
scale-up problems. However, an understanding of scale-up issues is rarely taught
in academia and may take years of industrial experience to acquire. Practical
Process Research & Development teaches how to anticipate and avoid these
problems when processes are being scaled up from the research lab or pilot
plant. The approach is pragmatic, with a minimum of theory and over 100
practical scale-up tips. Many tables and detailed reaction schemes allow the
reader to identify critical processing steps quickly. This practical guide is
essential reading for chemists and chemical engineers involved in industrial
process research and/or process development and for anyone seeking a clearer
understanding of how and why process R&D is conducted in the pharmaceutical
and fine chemicals industries.
KEY FEATURES
- Provides insights into generating rugged, practical,
cost-effective
processes for the chemical preparation of "small molecules"
- Breaks down process optimization into route, reagent,
and solvent selection,
development of reaction conditions, workup, crystallizations, and more
- Describes how to anticipate and avoid difficulties in
scaling up reactions
- Discusses guidelines for the timely development of
processes
- Illuminates principles with examples from the recent
literature
- Includes over 100 tips for rapid process
development
- Presents guidelines for implementing and
troubleshooting processes
- Written by an author with over 22 years experience in
process R&D in
- the pharmaceutical industry
Table of contents
- Foreword
- Approaches to Process Development
- Route Selection
- Reagent Selection
- Solvent Selection
- Running the Reaction
- Effects of Water
- In-Process Controls
- Optimizing the Reaction by Minimizing Impurities
- Optimizing Catalytic Reactions
- Work-Up
- Tools for Purifying the Product: Column Chromatography, Crystallization, and Reslurrying
- Final Product Form and Impurity Considerations
- Vessels and Mixing
- Preparing for and Implementing the Scale-up Run
- Troubleshooting
- Chiral Syntheses
- General Index
- Reaction Type Index
- Reagent Index
L'auteur - Neal G. Anderson
has worked for over 20 years in chemical process R&D
in the pharmaceutical industry. He earned a B.S. degree
from the University of Illinois and a Ph.D. in medicinal
chemistry from the University of Michigan and completed
post-doctoral studies at McNeil Laboratories. With almost
18 years in process R&D at Bristol-Myers Squibb Co. in
New Brunswick, New Jersey, Dr. Anderson has extensive
hands-on experience in the laboratory, pilot plant, and
manufacturing facilities. He has made key contributions to
processes for the manufacture of four major drug
substances, including captopril, and has participated in 12
manufacturing start-ups and successfully introduced many
processes to pilot plants. He received the Bristol-Myers
Squibb President's Award and spot awards, and his final
position was Principal Scientist.
Caractéristiques techniques
| PAPIER | |
| Éditeur(s) | Apress |
| Auteur(s) | Neal G. Anderson |
| Parution | 10/03/2000 |
| Nb. de pages | 354 |
| EAN13 | 9780120594757 |
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