Bioinformatics for geneticists

Michael R. Barnes, Ian C. Gray

422 pages, parution le 05/06/2003

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Résumé

This timely book illustrates the value of bioinformatics, not simply as a set of tools but rather as a science increasingly essential to navigate and manage the host of information generated by genomics and the availability of completely sequenced genomes.

Bioinformatics can be used at all stages of genetics research: to improve study design, to assist in candidate gene identification, to aid data interpretation and management and to shed light on the molecular pathology of disease-causing mutations. Written specifically for geneticists, this book explains the relevance of bioinformatics showing how it may be used to enhance genetic data mining and markedly improve genetic analysis.

Contributors : about 20 authors

An introduction to bioinformatics for the geneticist
- Introduction: The Role of Genetic Bioinformatics
- Internet Resources for the Geneticist
- Human Genetic Variation: Databases and Concepts
- Finding, Delineating and Analysing Genes

The impact of complete genome sequences on genetics
- Assembling a View of the Human Genome
- Mouse and Rat Genome Informatics
- Genetic and Physical Map Resources - An Integrated View

Bioinformatics for genetic study design
- From Linkage Peak to Culprit Gene: Following Up Linkage Analysis of Complex Phenotypes with #+Population-based Association Studies
- Genetic Studies from Genomic Sequence
- SNP Discovery and PCR-based Assay Design: From In Silico Data to the Laboratory Experiment
- Tools for Statistical Analysis of Genetic Data

Biological sequence analysis and characterization
- Predictive Functional Analysis of Polymorphisms: An Overview
- Functional In Silico Analysis of Non-coding SNPs
- Amino Acid Properties and Consequences of Substitutions

Genetics/genomics interfaces
- Gene Expression Informatics and Analysis
- Proteomic Informatics
- Concluding Remarks: Final Thoughts and Future Trends

Appendices
Glossary
Index

Caractéristiques techniques

	PAPIER
Éditeur(s)	Wiley
Auteur(s)	Michael R. Barnes, Ian C. Gray
Parution	05/06/2003
Nb. de pages	422
Format	15 x 23
Couverture	Broché
Poids	623g
Intérieur	Noir et Blanc
EAN13	9780470843949
ISBN13	978-0-470-84394-9