Apoptosis

The Life and Death of Cells

Christopher Potten, James Wilson

224 pages, parution le 03/11/2004

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Résumé

The concept of programmed cell death, or apoptosis, has exploded into a major scientific field of interest for cell biologists, oncologists, and many other biomedical researchers. Apoptosis occurs throughout the lifetime of most multicellular organisms. During development, for example, the selective death of cells is vital to remove tissue between the digits to produce fingers and toes. Apoptosis is also necessary to destroy cells that represent a threat to the integrity of the organism, for example cells infected by a virus. In many cancers the genes regulating apoptosis are defective, producing immortal, continuously proliferating cells. This book discusses the philosophical and technical difficulties in defining the moment of death for a cell, as well as the biological implications and significance of programmed cell death. Recent developments in the genetic control and interacting gene networks associated with apoptosis are presented. The book is written for advanced undergraduate and postgraduate students, and is highly illustrated to aid understanding.

L'auteur - Christopher Potten

Christopher Potten is Chairman and Scientific Director of EpiStem Ltd. and an Honorary Professor of Stem Cell Biology at the University of Manchester. He worked for many years in cancer research.

L'auteur - James Wilson

James Wilson is a Lecturer in Paediatric Gastroenterology at Bart's and The London, Queen Mary's School of Medicine and Dentistry.

Sommaire

Dead or alive
How to die
What to wear and who clears up the rubbish?
To reproduce or die?
The judge, the jury, and the executioner - the genes that control cell death
Stem cells
An in vivo system to study apoptosis : the small intestine
Cell death (apoptosis) in diverse systems
Measuring the levels of cell death (apoptosis)

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Caractéristiques techniques

	PAPIER
Éditeur(s)	Cambridge University Press
Auteur(s)	Christopher Potten, James Wilson
Parution	03/11/2004
Nb. de pages	224
Format	17,5 x 25
Couverture	Broché
Poids	498g
Intérieur	Noir et Blanc
EAN13	9780521626798
ISBN13	978-0-521-62679-8