Organic Chemistry

Structure and Function

K. Peter C. Vollhardt, Neil E. Schore

1210 pages, parution le 23/08/2002 (4^eme édition)

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Résumé

ABOUT THE COVER: Hailed as the last line of defense against bacteria, vancomycin is one of the most successful antibiotics used today against drug-resistant bacteria. First discovered by Eli Lilly and Company in 1956, this important natural product possesses a novel and challenging molecular architecture that withstood the attempts of synthetic chemists to construct it in the laboratory for many years. Recently, however, improved synthetic strategies and tactics led to its total synthesis independently by the groups of K. C. Nicolaou at The Scripps Research Institute and the University of California, San Diego (who provided the idea for the cover picture, based on that of Angewandte Chemie International Edition 1999, 38, issue 15), David A. Evans at Harvard University, and Dale L. Boger at The Scripps Research Institute. The front cover shows a molecule of vancomycin (as a ball-and-stick model) hovering over a picture of Streptococcus pyogenes, recent strains of which have shown dangerous drug resistance. The model of vancomycin wraps around to the back, on which we also depict the molecules of erythromycin (top) and penicillin (at right), two of the most celebrated antibiotics of all time. Synthetic strategies used to construct complex molecules, such as these three antibiotics, are discussed in Chapter 8 and subsequently throughout the text. The biological and medicinal context of organic molecules is addressed in many Chemical Highlights, such as Chemical Highlight 20-2, which specifically discusses the antibiotics on the cover, in the general text, and in numerous problems.

L'auteur - K. Peter C. Vollhardt

K. Peter C. Vollhardt - Docteur en chimie de l'University College de Londres, il a mené des recherches en chimie organique au California Institute of Technology, puis à l'Université de Californie, Berkeley. Il a reçu plusieurs prix et est l'auteur de nombreux articles.

L'auteur - Neil E. Schore

Neil E. Schore - Licencié en chimie de l'Université de Pennsylvanie, il est Professeur à l'Université de Californie, Davis. Ses qualités pédagogiques se sont vues récompensées par plusieurs prix.

Sommaire

Preface: A User's Guide to Organic Chemistry: Structure and Function
Structure and Bonding in Organic Molecules
Structure and Reactivity: Acids and Bases, Polar and Nonpolar Molecules
Reactions of Alkanes: Bond-Dissociation Energies, Radical Halogenation, and Relative Reactivity
Cyclic Alkanes
Stereoisomers
Properties and Reactions of Haloalkanes: Bimolecular Nucleophilic Substitution
Further Reactions of Haloalkanes: Unimolecular Substitution and Pathways of Elimination
Hydroxy Functional Group: Alcohols: Properties, Preparation, and Strategy of Synthesis
Further Reactions of Alcohols and the Chemistry Ethers
Using Nuclear Magnetic Resonance Spectroscopy to Deduce Structure
Alkenes and Infrared Spectroscopy
Reactions of Alkenes
Alkynes: The Carbon-Carbon Triple Bond
Delocalized Pi Systems: Investigation by Ultraviolet and Visible Spectroscopy
Benzene and Aromaticity: Electrophilic Aromatic Substitution
Electrophilic Attack on Derivatives of Benzene: Substituents Control Regioselectivity
Aldehydes and Ketones: The Carbonyl Group
Enols, Enolates, and the Aldol Condensation: α, β-Unssatured Aldehydes and Ketones
Carboxylic Acids
Carboxylic Acid Derivatives and Mass Spectrometry
Amines and Their Derivatives: Functional Groups Containing Nitrogen
Chemistry of Benzene Substituents: Alkylbenzenes, Phenols and Benzenamines
Enolates and the Claisen Condensation: Synthesis of β-Dicarbonyl Compounds; Acyl Anion Equivalents
Carbohydrates: Polyfunctional Compounds in Nature
Heterocycles: Heteroatoms in Cyclic Organic Compounds
Amino Acids, Peptides, Proteins, and Nucleic Acids: Nitrogen-Containing Polymers in Nature
MCAT Questions
Answers to Exercices
Photograph Credits
Index

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Caractéristiques techniques

	PAPIER
Éditeur(s)	W.H. Freeman and Company
Auteur(s)	K. Peter C. Vollhardt, Neil E. Schore
Parution	23/08/2002
Édition	4^eme édition
Nb. de pages	1210
Format	21 x 26
Couverture	Relié
Poids	2550g
Intérieur	Quadri
EAN13	9780716743743