Homocysteine

Related vitamins and neuropsychiatric disorders

Christina Bolander-Gouaille, Teodoro Bottiglieri

220 pages, parution le 03/08/2010 (2^eme édition)

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Résumé

During the last 15 years the research on homocysteine and the vitamins involved in its metabolism has become very dynamic. About 1,500 publications on the subject are now published each year. The research has long mainly focused on the association between homocysteine and cardiovascular disease, but also pregnancy complications/ fetal malformations. There is, however, an increasing interest in the connection between the homocysteine metabolism and neuropsychiatric disease with a steeply increasing number of publications. In particular, the association between homocysteine metabolism and cognitive decline/dementia attracts much interest. If simple, non-toxic homocysteine-lowering treatment with vitamins can reduce the incidence of, or delay the onset of dementia, it would have an enormous impact in societies with a rapidly increasing number of elderly at risk for dementia. This book summarises the research within the neuropsychiatric field, but also gives an overview of the underlying biochemistry and of diagnostic aspects. About 1,000 references are given.

Christina Bolander-Gouaille, a pharmacist, has for over 10 years specialised in writing reviews/monographs on homocysteine and related vitamins. This is her third book in a series edited by Springer Verlag. This book, however, is written in collaboration with Teodoro Bottiglieri, who is director of neuropharmacology and senior research scientist at Baylor University, Institute for Metabolic Diseases in Dallas, USA.

Sommaire

What is homocysteine?
The homocysteine metabolism
- The methylation cycle
- Common enzyme defects
How can hyperhomocysteinaemia be neurotoxic?
- Vascular damage
- Other mechanisms
Why do homocysteine levels increase?
- Lifestyle factors
- Age-related factors
- Hormonal changes
- Diseases
- Drugs
Neuropsychiatric conditions associated with hyperhomocysteinaemia
- Stroke
- Cognitive impairment/dementia
- Depression
- Other neuropsychiatric disorders
Impact of common enzyme defects on neuropsychiatric conditions
- Stroke
- Cognitive impairment/dementia
- Depression
- Other neuropsychiatric disorders
- Interactions with drug treatment
When and how to check the homocysteine levels
- When can hyperhomocysteinaemia be suspected?
- Blood sampling
- Methionine loading
How to interpret the test result and how to handle hyperhomocysteinaemia

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	PAPIER
Éditeur(s)	Springer
Auteur(s)	Christina Bolander-Gouaille, Teodoro Bottiglieri
Parution	03/08/2010
Édition	2^eme édition
Nb. de pages	220
Format	15,5 x 24
Couverture	Broché
Poids	485g
Intérieur	Quadri
EAN13	9782287225581
ISBN13	978-2-287-22558-1