Computational modeling of genetic and biochemical networks

James M. Bower, Hamid Bolouri

336 pages, parution le 08/04/2004

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Résumé

The advent of ever more sophisticated molecular manipulation techniques has made it clear that cellular systems are far more complex and dynamic than previously thought. At the same time, experimental techniques are providing an almost overwhelming amount of new data. It is increasingly apparent that linking molecular and cellular structure to function will require the use of new computational tools.

This book provides specific examples, across a wide range of molecular 2nd cellular systems, of how modeling techniques can be used to explore functionally relevant molecular and cellular relationships, the modeling techniques covered are applicable to cell, developmental, structural, and mathematical biology; genetics; and computational neuroscience. The book, intended as a primer for both theoretical and experimental biologists, is organized in two parts: models of gene activity and models of interactions among gene products. Modeling examples are provided at several scales for each subject. Each chapter includes an overview of the biological system in question and extensive references to important work in the area.

Sommaire

Modeling Genetic Networks
- Modeling the Activity of Single Genes
- A Probabilistic Model of a Prokaryotic Gene and Its Regulation
- A Logical Model of m-Regulatory Control in a Eukaryotic System
- Trainable Gene Regulation Networks with Application to Drosophila Pattern Formation
- Genetic Network Inference in Computational Models and Applications to Large-Scale Gene Expression Data
Modeling Biochemical Networks
- Atomic-Level Simulation and Modeling of Biomacromolecules
- Diffusion
- Kinetic Models of Excitable Membranes and Synaptic Interactions
- Stochastic Simulation of Cell Signaling Pathways
- Analysis of Complex Dynamics in Cell Cycle Regulation
- Simplifying and Reducing Complex Models

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Caractéristiques techniques

	PAPIER
Éditeur(s)	The MIT Press
Auteur(s)	James M. Bower, Hamid Bolouri
Parution	08/04/2004
Nb. de pages	336
Format	17,7 x 22,8
Couverture	Broché
Poids	721g
Intérieur	Noir et Blanc
EAN13	9780262524230
ISBN13	978-0-262-52423-0