Probability Models for DNA Sequence Evolution

Probability and Its Applications

Rick Durrett - Collection Probability and Its Applications

240 pages, parution le 31/05/2002

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Résumé

Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability? To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigation of various statistical tests to detect departures from "neutral evolution." The final chapter studies the evolution of whole genomes by chromosomal inversions, reciprocal translocations, and genome duplication.

Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies from the biology literature that illustrate the use of these results. This book is written for mathematicians and for biologists alike. We assume no previous knowledge of concepts from biology and only a basic knowledge of probability: a one semester undergraduate course and some familiarity with Markov chains and Poisson processes.

L'auteur - Rick Durrett

Rick Durrett received his Ph.D. in operations research from Stanford University in 1976. He taught in the UCLA mathematics department before coming to Cornell in 1985. He is the author of six books and 125 research papers, and is the academic father of more than 30 Ph.D. students. His current interests are the use of probability models in genetics and ecology, and decreasing the mean and variance of his golf score.

Sommaire

Basic Models
Neutral Complications
Natural Selection
Statistical Tests
Genome Rearrangement

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Caractéristiques techniques

	PAPIER
Éditeur(s)	Springer
Auteur(s)	Rick Durrett
Collection	Probability and Its Applications
Parution	31/05/2002
Nb. de pages	240
Format	16 x 24
Couverture	Relié
Poids	472g
Intérieur	Noir et Blanc
EAN13	9780387954356
ISBN13	978-0-387-95435-6